JNK1 from Hematopoietic Cells Mediates Progression from Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK) plays a pivotal role in the development of the metabolic syndrome including NAFLD. However, the mechanism underlying the contribution of JNK to the progression from simple steatosis to steatohepatitis and liver fibrosis is unresolved. METHODS: Hep...

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Bibliografiske detaljer
Main Authors: Kodama, Yuzo, Kisseleva, Tatiana, Iwaisako, Keiko, Miura, Kouichi, Taura, Kojiro, De Minicis, Samuele, Österreicher, Christoph H., Schnabl, Bernd, Seki, Ekihiro, Brenner, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757473/
https://ncbi.nlm.nih.gov/pubmed/19549522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.06.045
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