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Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90: COMPUTATIONAL ANALYSIS AND PROTEIN ENGINEERING

The Hsp-organizing protein (HOP) binds to the C termini of the chaperones Hsp70 and Hsp90, thus bringing them together so that substrate proteins can be passed from Hsp70 to Hsp90. Because Hsp90 is essential for the correct folding and maturation of many oncogenic proteins, it has become a significa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kajander, Tommi, Sachs, Jonathan N., Goldman, Adrian, Regan, Lynne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757238/
https://ncbi.nlm.nih.gov/pubmed/19586912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033894
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