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Protein Kinase A Increases Type-2 Inositol 1,4,5-Trisphosphate Receptor Activity by Phosphorylation of Serine 937

Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) represents a mechanism for shaping intracellular Ca(2+) signals following a concomitant elevation in cAMP. Activation of PKA results in enhanced Ca(2+) release in cells that express predominantly InsP(3)R2....

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Detalhes bibliográficos
Main Authors: Betzenhauser, Matthew J., Fike, Jenna L., Wagner, Larry E., Yule, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757215/
https://ncbi.nlm.nih.gov/pubmed/19608738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010132
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