טוען...
Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway
Mitochondrial respiratory complex II inhibition plays a central role in Huntington’s disease (HD). Remarkably, 3-NP, a complex II inhibitor, recapitulates HD-like symptoms. Furthermore, decreases in mitochondrial fusion or increases in mitochondrial fission have been implicated in neurodegenerative...
שמור ב:
| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757037/ https://ncbi.nlm.nih.gov/pubmed/19300456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.22 |
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