Mutant SOD1(G93A) Triggers Mitochondrial Fragmentation in Spinal Cord Motor Neurons: Neuroprotection by SIRT3 and PGC-1α

Mutations in the Cu/Zn Superoxide Dismutase (SOD1) gene cause an inherited form of ALS with upper and lower motor neuron loss. The mechanism underlying mutant SOD1-mediated motor neuron degeneration remains unclear. While defects in mitochondrial dynamics contribute to neurodegeneration, including A...

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Detaylı Bibliyografya
Asıl Yazarlar: Song, Wenjun, Song, Yuting, Kincaid, Brad, Bossy, Blaise, Bossy-Wetzel, Ella
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992938/
https://ncbi.nlm.nih.gov/pubmed/22819776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.07.004
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