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The Nucleoside Analog D-carba T Blocks HIV-1 Reverse Transcription
A major pathway for HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs) involves reverse transcriptase (RT) mutations that enhance ATP-dependent pyrophosphorolysis, which excises NRTIs from the end of viral DNA. We analyzed novel NRTIs for their ability to inhibit DNA synthesis o...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756836/ https://ncbi.nlm.nih.gov/pubmed/19678643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801176e |
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