Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

The role of GTP hydrolysis in microtubule dynamics has been reinvestigated using an analogue of GTP, guanylyl-(alpha, beta)-methylene-diphosphonate (GMPCPP). This analogue binds to the tubulin exchangeable nucleotide binding site (E-site) with an affinity four to eightfold lower than GTP and promote...

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Publié dans:	Mol Biol Cell
Auteurs principaux:	Hyman, A A, Salser, S, Drechsel, D N, Unwin, N, Mitchison, T J
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Cell Biology 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1421572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.3.10.1155
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