Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of EZH2 mediates the histone methyltransferase activity. This induces trimethylation of lysine 27 on histone H3, regulates the expre...

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Hauptverfasser: Fiskus, Warren, Wang, Yongchao, Sreekumar, Arun, Buckley, Kathleen M., Shi, Huidong, Jillella, Anand, Ustun, Celalettin, Rao, Rekha, Fernandez, Pravina, Chen, Jianguang, Balusu, Ramesh, Koul, Sanjay, Atadja, Peter, Marquez, Victor E., Bhalla, Kapil N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756128/
https://ncbi.nlm.nih.gov/pubmed/19638619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213496
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