Absence of IFN-β impairs antigen presentation capacity of splenic dendritic cells via down-regulation of Hsp70

Type I interferons (IFNs) play a key role in linking the innate and adaptive arms of the immune system. Although produced rapidly in response to pathogens, IFNs are also produced at low levels in the absence of infection. In the present study we demonstrate that constitutively produced IFNs are nece...

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Main Authors: Ziętara, Natalia, Łyszkiewicz, Marcin, Gekara, Nelson, Puchałka, Jacek, Martins Dos Santos, Vitor A.P., Hunt, Clayton R., Pandita, Tej K., Lienenklaus, Stefan, Weiss, Siegfried
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756009/
https://ncbi.nlm.nih.gov/pubmed/19581626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803214
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