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Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat

We have recently reported that transgenic (mRen2)27 rats (Ren2 rats) exhibit pulmonary arterial hypertension (PAH), which is, in part, mediated by oxidative stress. Since 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) exhibit beneficial vascular effects independent of cholesterol synt...

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Detalhes bibliográficos
Main Authors: DeMarco, Vincent G., Habibi, Javad, Whaley-Connell, Adam T., Schneider, Rebecca I., Sowers, James R., Andresen, Bradley T., Gutweiler, Alex A., Ma, Lixin, Johnson, Megan S., Ferrario, Carlos M., Dellsperger, Kevin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755976/
https://ncbi.nlm.nih.gov/pubmed/19633211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00048.2009
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