Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat

Renin-angiotensin-aldosterone system (RAAS) activation mediates increases in reactive oxygen species (ROS) and impaired insulin signaling. The transgenic Ren2 rat manifests increased tissue renin-angiotensin system activity, elevated serum aldosterone, hypertension, and insulin resistance. To explor...

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Main Authors: Lastra, Guido, Whaley-Connell, Adam, Manrique, Camila, Habibi, Javad, Gutweiler, Alex A., Appesh, Lama, Hayden, Melvin R., Wei, Yongzhong, Ferrario, Carlos, Sowers, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493595/
https://ncbi.nlm.nih.gov/pubmed/18445755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00258.2007
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