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Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat

We have recently reported that transgenic (mRen2)27 rats (Ren2 rats) exhibit pulmonary arterial hypertension (PAH), which is, in part, mediated by oxidative stress. Since 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) exhibit beneficial vascular effects independent of cholesterol synt...

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Hlavní autoři: DeMarco, Vincent G., Habibi, Javad, Whaley-Connell, Adam T., Schneider, Rebecca I., Sowers, James R., Andresen, Bradley T., Gutweiler, Alex A., Ma, Lixin, Johnson, Megan S., Ferrario, Carlos M., Dellsperger, Kevin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755976/
https://ncbi.nlm.nih.gov/pubmed/19633211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00048.2009
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