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Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that signals through the interaction of type I (TβRI) and type II (TβRII) receptors to activate distinct intracellular pathways. TAK1 is a serine/threonine kinase that is rapidly activated by TGF-β1. However, the molecular mechanis...

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Detalhes bibliográficos
Main Authors: Kim, Sung Il, Kwak, Joon Hyeok, Na, Hee-Jun, Kim, Jin Kuk, Ding, Yan, Choi, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755952/
https://ncbi.nlm.nih.gov/pubmed/19556242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007146
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