Depletion of Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatases 1 and 2 by Bcr-Abl Promotes Chronic Myelogenous Leukemia Cell Proliferation through Continuous Phosphorylation of Akt Isoforms

The constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway commonly occurs in cancers and is a crucial event in tumorigenesis. Chronic myelogenous leukemia (CML) is characterized by a reciprocal chromosomal translocation (9;22) that generates the Bcr-Abl fusion gene. The PI3...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hirano, Isao, Nakamura, Satoki, Yokota, Daisuke, Ono, Takaaki, Shigeno, Kazuyuki, Fujisawa, Shinya, Shinjo, Kaori, Ohnishi, Kazunori
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Molecular Basis of Cell and Developmental Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755940/
https://ncbi.nlm.nih.gov/pubmed/19261608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808182200
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