Reduction of Raf Kinase Inhibitor Protein Expression by Bcr-Abl Contributes to Chronic Myelogenous Leukemia Proliferation

Chronic myelogenous leukemia (CML) is characterized by a reciprocal chromosomal translocation (9;22) that generates the Bcr-Abl fusion gene. The Ras/Raf-1/MEK/ERK pathway is constitutively activated in Bcr-Abl-transformed cells, and Ras activity enhances the oncogenic ability of Bcr-Abl. However, th...

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Detalhes bibliográficos
Main Authors: Takemura, Tomonari, Nakamura, Satoki, Yokota, Daisuke, Hirano, Isao, Ono, Takaaki, Shigeno, Kazuyuki, Fujisawa, Shinya, Ohnishi, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825454/
https://ncbi.nlm.nih.gov/pubmed/20028985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075788
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