Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases

Density-enhanced phosphatase-1 (DEP-1) is a trans-membrane receptor protein-tyrosine phosphatase that plays a recognized prominent role as a tumor suppressor. However, the mechanistic details underlying its function are poorly understood because its primary physiological substrate(s) have not been f...

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Bibliografiske detaljer
Main Authors: Sacco, Francesca, Tinti, Michele, Palma, Anita, Ferrari, Emanuela, Nardozza, Aurelio P., van Huijsduijnen, Rob Hooft, Takahashi, Takamune, Castagnoli, Luisa, Cesareni, Gianni
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755929/
https://ncbi.nlm.nih.gov/pubmed/19494114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002758
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