The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity: INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS

It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC. Herein, we examine the affect of HNO donors on the act...

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Autors principals: Miller, Thomas W., Cherney, Melisa M., Lee, Andrea J., Francoleon, Nestor E., Farmer, Patrick J., King, S. Bruce, Hobbs, Adrian J., Miranda, Katrina M., Burstyn, Judith N., Fukuto, Jon M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755905/
https://ncbi.nlm.nih.gov/pubmed/19531488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014282
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