The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity: INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS

It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC. Herein, we examine the affect of HNO donors on the act...

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Detalhes bibliográficos
Main Authors: Miller, Thomas W., Cherney, Melisa M., Lee, Andrea J., Francoleon, Nestor E., Farmer, Patrick J., King, S. Bruce, Hobbs, Adrian J., Miranda, Katrina M., Burstyn, Judith N., Fukuto, Jon M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755905/
https://ncbi.nlm.nih.gov/pubmed/19531488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014282
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