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Heterogeneous Nuclear Ribonucleoprotein K Represses the Production of Pro-apoptotic Bcl-x(S) Splice Isoform
The Bcl-x pre-mRNA is alternatively spliced to produce the anti-apoptotic Bcl-x(L) and the pro-apoptotic Bcl-x(S) isoforms. By performing deletion mutagenesis on a human Bcl-x minigene, we have identified a novel exonic element that controls the use of the 5′ splice site of Bcl-x(S). The proximal po...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2755870/ https://ncbi.nlm.nih.gov/pubmed/19520842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019711 |
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