Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

Analysis of human heart mitochondrial DNA (mtDNA) by electron microscopy and agarose gel electrophoresis revealed a complete absence of the θ-type replication intermediates seen abundantly in mtDNA from all other tissues. Instead only Y- and X-junctional forms were detected after restriction digesti...

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Main Authors: Pohjoismäki, Jaakko L. O., Goffart, Steffi, Tyynismaa, Henna, Willcox, Smaranda, Ide, Tomomi, Kang, Dongchon, Suomalainen, Anu, Karhunen, Pekka J., Griffith, Jack D., Holt, Ian J., Jacobs, Howard T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755869/
https://ncbi.nlm.nih.gov/pubmed/19525233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016600
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