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Sizing of single fluorescently stained DNA fragments by scanning microscopy

We describe an approach to determine DNA fragment sizes based on the fluorescence detection of single adsorbed fragments on specifically coated glass cover slips. The brightness of single fragments stained with the DNA bisintercalation dye TOTO-1 is determined by scanning the surface with a confocal...

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Bibliografische gegevens
Hoofdauteurs: Laib, Stephan, Rankl, Michael, Ruckstuhl, Thomas, Seeger, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC275575/
https://ncbi.nlm.nih.gov/pubmed/14602931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gng138
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