Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design

Sperm glyceraldehyde-3-phosphate dehydrogenase has been shown to be a successful target for a non-hormonal contraceptive approach, but the agents tested to date have had unacceptable side effects. Obtaining the structure of the sperm-specific isoform to allow rational inhibitor design has therefore...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Frayne, Jan, Taylor, Abby, Cameron, Gus, Hadfield, Andrea T.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2009
الموضوعات:
Protein Structure and Folding
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755679/
https://ncbi.nlm.nih.gov/pubmed/19542219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004648
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