Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an important glycolytic enzyme, has a non-catalytic (thus a non-canonical) role in inducing mitochondrial elimination under oxidative stress. We recently demonstrated that phosphorylation of GAPDH by δ protein kinase C (δPKC) inhibits this GAPDH-depe...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Qvit, Nir, Joshi, Amit U., Cunningham, Anna D., Ferreira, Julio C. B., Mochly-Rosen, Daria
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919446/
https://ncbi.nlm.nih.gov/pubmed/27129213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711630
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