Hyperphosphorylation and Aggregation of Tau in Laforin-deficient Mice, an Animal Model for Lafora Disease

Lafora progressive myoclonous epilepsy (Lafora disease; LD) is caused by mutations in the EPM2A gene encoding a dual specificity protein phosphatase named laforin. Our analyses on the Epm2a gene knock-out mice, which developed most of the symptoms of LD, reveal the presence of hyperphosphorylated Ta...

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Bibliografiske detaljer
Main Authors: Puri, Rajat, Suzuki, Toshimitsu, Yamakawa, Kazuhiro, Ganesh, Subramaniam
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755673/
https://ncbi.nlm.nih.gov/pubmed/19542233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.009688
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