Cathepsin L Plays a Major Role in Cholecystokinin Production in Mouse Brain Cortex and in Pituitary AtT-20 Cells: Protease Gene Knockout and Inhibitor Studies

Cholecystokinin (CCK) is a peptide neurotransmitter whose production requires proteolytic processing of the proCCK precursor to generate active CCK8 neuropeptide in brain. This study demonstrates the significant role of the cysteine protease cathepsin L for CCK8 production. In cathepsin L knockout (...

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Main Authors: Beinfeld, Margery C., Funkelstein, Lydiane, Foulon, Thierry, Cadel, Sandrine, Kitagawa, Kouki, Toneff, Thomas, Reinheckel, Thomas, Peters, Christoph, Hook, Vivian
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755599/
https://ncbi.nlm.nih.gov/pubmed/19589362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2009.06.030
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