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Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression
The pituitary hormones adrenocorticotropic hormone (ACTH), β-endorphin, and α-melanocyte stimulating hormone (α-MSH) are synthesized by proteolytic processing of their common proopiomelanocortin (POMC) precursor. Key findings from this study show that cathepsin L functions as a major proteolytic enz...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2602888/ https://ncbi.nlm.nih.gov/pubmed/18849346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709010200 |
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