Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression

The pituitary hormones adrenocorticotropic hormone (ACTH), β-endorphin, and α-melanocyte stimulating hormone (α-MSH) are synthesized by proteolytic processing of their common proopiomelanocortin (POMC) precursor. Key findings from this study show that cathepsin L functions as a major proteolytic enz...

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Detalhes bibliográficos
Main Authors: Funkelstein, Lydiane, Toneff, Thomas, Mosier, Charles, Hwang, Shin-Rong, Beuschlein, Felix, Lichtenauer, Urs D., Reinheckel, Thomas, Peters, Christoph, Hook, Vivian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602888/
https://ncbi.nlm.nih.gov/pubmed/18849346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709010200
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