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p53 stimulates human topoisomerase I activity by modulating its DNA binding
The tumor suppressor protein p53 and the human DNA topoisomerase I (htopoI) interact with each other, which leads to a stimulation of the catalytic activity of htopoI. Moreover, p53 stimulates the topoisomerase I-induced recombination repair (TIRR) reaction. However, little was known about how p53 s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC275542/ https://ncbi.nlm.nih.gov/pubmed/14602918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg846 |
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