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Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing

We investigated whether a continuous transcript is necessary for co-transcriptional pre-mRNA processing. Cutting an intron with the fast-cleaving hepatitis δ ribozyme, but not the slower hammerhead, inhibited splicing. Exon tethering to RNA pol II therefore cannot rescue splicing of a transcript sev...

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Autori principali: Fong, Nova, Ohman, Marie, Bentley, David L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755206/
https://ncbi.nlm.nih.gov/pubmed/19701200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1652
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