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c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.

The proto-oncogene c-Kit, a transmembrane receptor tyrosine kinase, is an important regulator of cell growth whose constitutively active oncogenic counterpart, v-kit, induces sarcomas in cats. Mutations in murine c-kit that reduce the receptor tyrosine kinase activity cause deficiencies in the migra...

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Dettagli Bibliografici
Autori principali: Funasaka, Y, Boulton, T, Cobb, M, Yarden, Y, Fan, B, Lyman, S D, Williams, D E, Anderson, D M, Zakut, R, Mishima, Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC275519/
https://ncbi.nlm.nih.gov/pubmed/1372524
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