RNA polymerase II is Hyperphosphorylated in Response to Topoisomerase I-DNA Cleavage Complexes and is Associated with Transcription- and BRCA1-Dependent Degradation of Topoisomerase I

The progression of RNA polymerase II can be blocked by lesions on the DNA template. In this study, we focused in the modifications of the largest subunit of RNA polymerase II, Rpb1, in response to stabilized topoisomerase I (Top1)-DNA cleavage complexes. In addition to DNA modifications (base damage...

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Detalhes bibliográficos
Main Authors: Sordet, Olivier, Larochelle, Stéphane, Nicolas, Estelle, Stevens, Ellen V., Zhang, Chao, Shokat, Kevan M., Fisher, Robert P., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754794/
https://ncbi.nlm.nih.gov/pubmed/18588899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.028
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