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Onconase cytotoxicity relies on the distribution of its positive charge
Onconase® (ONC) is a member of the ribonuclease A superfamily that is toxic to cancer cells in vitro and in vivo. ONC is now in Phase IIIb clinical trials for the treatment of malignant mesothelioma. Internalization of ONC to the cytosol of cancer cells is essential for its cytotoxic activity, despi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754565/ https://ncbi.nlm.nih.gov/pubmed/19523116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07098.x |
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