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Arginine Residues are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase
Onconase is an amphibian member of the pancreatic ribonuclease family of enzymes that is in clinical trials for the treatment of cancer. Onconase, which has an abundance of lysine residues, is internalized by cancer cells through endocytosis in a mechanism similar to that of cell-penetrating peptide...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234306/ https://ncbi.nlm.nih.gov/pubmed/21980976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200979k |
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