DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes

BACKGROUND: Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein (DNA-HSP65) displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protection was attributed to induction of a strong cellular immunity against HSP65. A...

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Autores principales: Santos, Rubens R, Sartori, Alexandrina, Lima, Deison S, Souza, Patrícia RM, Coelho-Castelo, Arlete AM, Bonato, Vânia LD, Silva, Célio L
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754477/
https://ncbi.nlm.nih.gov/pubmed/19754943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-8518-7-4
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