Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis

BACKGROUND: The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in ~30% of human breast cancers. Phosphorylation of the translation initiation factor, eIF2α inhibits global protein synthesis and activates a stress signaling and growth suppressive program. We have shown that forced phosphorylati...

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Autores principales: Sequeira, Sharon J, Wen, Huei Chi, Avivar-Valderas, Alvaro, Farias, Eduardo F, Aguirre-Ghiso, Julio A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754445/
https://ncbi.nlm.nih.gov/pubmed/19754954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-64
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