Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation

Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2α. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth through cell cycle arrest and/or apoptosis. These respon...

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Detalhes bibliográficos
Main Authors: Sequeira, Sharon J., Ranganathan, Aparna C., Adam, Alejandro P., Iglesias, Bibiana V., Farias, Eduardo F., Aguirre-Ghiso, Julio A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1910610/
https://ncbi.nlm.nih.gov/pubmed/17637831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000615
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