Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

Stimulation of CD40 or Toll-Like Receptors (TLR) has potential for tumor immunotherapy. Combinations of CD40 and TLR stimulation can be synergistic, resulting in even stronger dendritic cell (DC) and CD8+ T cell responses. To evaluate such combinations, established B16F10 melanoma tumors were inject...

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Bibliografiske detaljer
Main Authors: Stone, Geoffrey W., Barzee, Suzanne, Snarsky, Victoria, Santucci, Camila, Tran, Brian, Langer, Robert, Zugates, Gregory T., Anderson, Daniel G., Kornbluth, Richard S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754331/
https://ncbi.nlm.nih.gov/pubmed/19812695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007334
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