A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes

Nurr1, an orphan nuclear receptor, plays an essential role in the generation and maintenance of dopaminergic neurons in the brain. Rare mutations in Nurr1 are associated with familial Parkinson’s disease, but the underlying basis for this relationship has not been established. Here, we demonstrate t...

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Hlavní autoři: Saijo, Kaoru, Winner, Beate, Carson, Christian T., Collier, Jana G., Boyer, Leah, Rosenfeld, Michael G., Gage, Fred H., Glass, Christopher K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754279/
https://ncbi.nlm.nih.gov/pubmed/19345186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.01.038
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