A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes

Nurr1, an orphan nuclear receptor, plays an essential role in the generation and maintenance of dopaminergic neurons in the brain. Rare mutations in Nurr1 are associated with familial Parkinson’s disease, but the underlying basis for this relationship has not been established. Here, we demonstrate t...

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Bibliografiske detaljer
Main Authors: Saijo, Kaoru, Winner, Beate, Carson, Christian T., Collier, Jana G., Boyer, Leah, Rosenfeld, Michael G., Gage, Fred H., Glass, Christopher K.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754279/
https://ncbi.nlm.nih.gov/pubmed/19345186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.01.038
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