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Dereplication and De Novo Sequencing of Nonribosomal Peptides
Nonribosomal peptides (NRPs) are of great pharmacological importance, but there is currently no technology for high-throughput NRP dereplication and sequencing. We employ multi-stage mass spectrometry followed by spectral alignment algorithms for sequencing of cyclic NRPs. We also present an algorit...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754211/ https://ncbi.nlm.nih.gov/pubmed/19597502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1350 |
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