Dereplication and De Novo Sequencing of Nonribosomal Peptides

Nonribosomal peptides (NRPs) are of great pharmacological importance, but there is currently no technology for high-throughput NRP dereplication and sequencing. We employ multi-stage mass spectrometry followed by spectral alignment algorithms for sequencing of cyclic NRPs. We also present an algorit...

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Bibliografiska uppgifter
Huvudupphovsmän: Ng, Julio, Bandeira, Nuno, Liu, Wei-Ting, Ghassemian, Majid, Simmons, Thomas L., Gerwick, William, Linington, Roger, Dorrestein, Pieter, Pevzner, Pavel
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754211/
https://ncbi.nlm.nih.gov/pubmed/19597502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1350
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