Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury

HIV-1 Nef induces podocyte proliferation and dedifferentiation by activating the Stat3 and MAPK1,2 pathways. Activation of Stat3 also occurs in human kidneys affected by HIV-associated nephropathy (HIVAN), but its contribution to the development of HIVAN is unknown. Here, we generated HIV-1 transgen...

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Bibliographic Details
Main Authors:	Feng, Xiaobei, Lu, Ting-Chi, Chuang, Peter Y., Fang, Wei, Ratnam, Krishna, Xiong, Huabao, Ouyang, Xinshou, Shen, Yuhong, Levy, David E., Hyink, Deborah, Klotman, Mary, D'Agati, Vivette, Iyengar, Ravi, Klotman, Paul E., He, John C.
Format:	Artigo
Language:	Inglês
Published:	American Society of Nephrology 2009
Subjects:	Basic Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2754106/ https://ncbi.nlm.nih.gov/pubmed/19608706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008080879
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Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury

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