Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy

Recent studies suggest that Stat3, a transcription factor that mediates cytokine signaling, plays a critical role in the pathogenesis of diabetic nephropathy. Complete Stat3 gene knockout is embryonic lethal; therefore, we crossed Stat3+/– mice with Stat3 mutant mice (SA/SA) that lack full Stat3 act...

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Autores principales: Lu, Ting-Chi, Wang, Zhao-Hui, Feng, Xiaobei, Chuang, Peter Y., Fang, Wei, Shen, Yuhong, Levy, David E., Xiong, Huabao, Chen, Nan, He, John Cijiang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888596/
https://ncbi.nlm.nih.gov/pubmed/19357722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2009.98
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