Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-γ secretion by antigen-specific CD8 T cells

DNA vaccination is a novel immunization strategy that has great potential for the development of vaccines and immune therapeutics. This strategy has been highly effective in mice, but is less immunogenic in non-human primates and in humans. Enhancing DNA vaccine potency remains a challenge. It is li...

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Autores principales: Muthumani, Gowtham, Laddy, Dominick J, Sundaram, Senthil G, Fagone, Paolo, Shedlock, Devon J, Kannan, Senthil, Wu, Ling, Chung, Christopher W, Lankaraman, Karthikbabu Mallil, Burns, John, Muthumani, Karuppiah, Weiner, David B
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753964/
https://ncbi.nlm.nih.gov/pubmed/19740322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03044.x
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