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Tumor-Shed PGE(2) Impairs IL2Rγc-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins
BACKGROUND: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of this immunomodulator in the survival of T helper cells remained unclear. Since...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753647/ https://ncbi.nlm.nih.gov/pubmed/19812686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007382 |
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