Tumor-Shed PGE(2) Impairs IL2Rγc-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins

BACKGROUND: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of this immunomodulator in the survival of T helper cells remained unclear. Since...

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Bibliografski detalji
Glavni autori: Chattopadhyay, Sreya, Bhattacharyya, Sankar, Saha, Baisakhi, Chakraborty, Juni, Mohanty, Suchismita, Sakib Hossain, Dewan Md., Banerjee, Shuvomoy, Das, Kaushik, Sa, Gaurisankar, Das, Tanya
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753647/
https://ncbi.nlm.nih.gov/pubmed/19812686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007382
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