Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells

Tumor suppressor p53 plays the central role in regulating apoptosis in response to genotoxic stress. From an evolutionary perspective, the activity of p53 has to be backed up by other protein(s) in case of any functional impairment of this protein, to trigger DNA damage-induced apoptosis in cancer c...

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Detalhes bibliográficos
Main Authors: Chakraborty, Juni, Banerjee, Shuvomoy, Ray, Pallab, Hossain, Dewan Md. Sakib, Bhattacharyya, Sankar, Adhikary, Arghya, Chattopadhyay, Sreya, Das, Tanya, Sa, Gaurisankar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963387/
https://ncbi.nlm.nih.gov/pubmed/20675383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122705
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