The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response t...

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Main Authors: Billharz, Rosalind, Zeng, Hui, Proll, Sean C., Korth, Marcus J., Lederer, Sharon, Albrecht, Randy, Goodman, Alan G., Rosenzweig, Elizabeth, Tumpey, Terrence M., García-Sastre, Adolfo, Katze, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753112/
https://ncbi.nlm.nih.gov/pubmed/19706713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00330-09
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