Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-α) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-α Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection

The influenza pandemic of 1918 to 1919 was one of the worst global pandemics in recent history. The highly pathogenic nature of the 1918 virus is thought to be mediated in part by a dysregulation of the host response, including an exacerbated proinflammatory cytokine response. In the present study,...

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Main Authors: Belisle, Sarah E., Tisoncik, Jennifer R., Korth, Marcus J., Carter, Victoria S., Proll, Sean C., Swayne, David E., Pantin-Jackwood, Mary, Tumpey, Terrence M., Katze, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004331/
https://ncbi.nlm.nih.gov/pubmed/20926563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01310-10
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