Synthetic Microcin C Analogs Targeting Different Aminoacyl-tRNA Synthetases

Microcin C (McC) is a potent antibacterial agent produced by some strains of Escherichia coli. McC consists of a ribosomally synthesized heptapeptide with a modified AMP attached through a phosphoramidate linkage to the α-carboxyl group of the terminal aspartate. McC is a Trojan horse inhibitor: it...

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Main Authors: Van de Vijver, Pieter, Vondenhoff, Gaston H. M., Kazakov, Teymur S., Semenova, Ekaterina, Kuznedelov, Konstantin, Metlitskaya, Anastasia, Van Aerschot, Arthur, Severinov, Konstantin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Enzymes and Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753047/
https://ncbi.nlm.nih.gov/pubmed/19684138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00829-09
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