The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice

CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG(6)-run) conjugation to PE CpG-ODN has been reported to enhance immunostimulati...

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Bibliografske podrobnosti
Main Authors: Chang, Yoon-Seok, Kim, Yoon-Keun, Kwon, Hyouk-Soo, Park, Heung-Woo, Min, Kyung-Up, Kim, You-Young, Cho, Sang-Heon
Format: Artigo
Jezik:Inglês
Izdano: The Korean Academy of Medical Sciences 2009
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752769/
https://ncbi.nlm.nih.gov/pubmed/19794984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2009.24.5.860
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