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Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response
Tamoxifen continues to be a standard endocrine therapy for the prevention and treatment of estrogen receptor (ER)-positive breast cancer. Tamoxifen can be considered a classic “pro-drug,” requiring metabolic activation to elicit pharmacological activity. CYP2D6 is the rate-limiting enzyme catalyzing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752373/ https://ncbi.nlm.nih.gov/pubmed/17882159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.clpt.6100367 |
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